Vitamin B12 (cyanocobalamin): Benefits, Side Effects, Dosage & More GoodRx Understanding Vitamin B12 Deficiency in Cancer Patients High dose vitamin B12 supplements can sometimes cause side effects, including headache, nausea, vomiting, mild diarrhea, itching, skin rash, tiredness, weakness, or tingling in the hands and feet. OC: Only One Chance B12 Deficiency Pernicious Anaemia Society
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