Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Pentose Phosphate Pathway: ditki medical and biological sciences The headline Tylenol causes autism has sparked concern. But the science tells a more nuanced story. Some observational studies have found that when pregnant women used more acetaminophen, their Mark Hyman, Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar