Glutathione as a Cerebral Substrate in Depressive Behavior Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect New research indicates a correlation between depression and reduced levels of antioxidants in the . Specifically, studies show that individuals with depression often exhibit lower levels of antioxidant enzymes like glutathione and Dietary supplementations and depression JMDH Dove Medical Press