Glucose 6 Phosphate Dehydrogenase Deficiency Oncohema Key The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID 19 ScienceDirect In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Medications and Glucose 6 Phosphate Dehydrogenase : Drug Safety