Cold sore triggers vary from person to person, but HSV is an opportunistic infection. That means it rears its ugly head when, for whatever reason, your immune system is too weak to TMEFF1 is a neuron specific restriction factor for herpes simplex virus Nature HSV 1 induced N6 methyladenosine reprogramming via ICP0 mediated suppression of METTL14 potentiates oncolytic activity in glioma ScienceDirect Manipulation of Oxidative Stress Responses by Non Thermal Plasma to Treat Herpes Simplex Virus Type 1 Infection and Disease