Martina Big, 36, who is from Germany, and her husband Michael Eurwen, 38, who both injected Melanotan, a synthetic hormone to darken their skin have announced that they are planning to permanently Melanotan 2 Day 4: Whacky Side Effects. , I am cutting back from daily use and probably using once a week from here on out. , Zero appetite, Fatigue, And what I think was sleep paralysis , And yes Melanotan II (Tan Jabs): Why They're Not Worth The Risk Melanotan II injection resulting in systemic toxicity and rhabdomyolysis