ACETAMINOPHEN DOSING AND TOXICITY Acetaminophen metabolism and NAPQI mediated mitochondrial effects Download Scientific Diagram The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism William Parker, Chi Dang Hornik, Staci Bilbo, Zoie E. Holzknecht, Lauren Gentry, Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading