GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Full article: Interactions of glutathione transferases with 4 hydroxynonenal Crystal structures of glutathione and inhibitor bound human GGT1: critical interactions within the cysteinylglycine binding site Journal of Biological Chemistry Glutathione Pathways
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glutathione reaction Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes