View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism Jenny McCarthy on Acetaminophen, Vaccines, and Autism Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.