Is it Safe to Combine Glutathione with Alcohol? Expert Advice Heavy drinkers might want to reconsider any kind of acetaminophen! The liver uses a substance called glutathione to help minimize the toxic effects of metabolizing acetaminophen. Alcohol is also metabolized in the Glutathione found to significantly reduce acetaldehyde levels and help relieve hangovers Let's be honest; summer is for socializing, relaxing, and for some, enjoying a drink or two. No judgment; just here to help you do it smarter. Enter glutathione, your body's master antioxidant.