Rasburicase Induced Hemolytic Anemia Secondary to Undiagnosed G6PD Deficiency Published in Journal of Brown Hospital Medicine In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Glucose 6 Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus Clinics in Perinatology Diagram showing red cell response to oxidative damage from drugs. (A). Download Scientific Diagram