How to increase glutathione levels: 4 natural ways Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Sulforaphane potently activates the Nrf2 pathway, upregulating stress response genes similar to exercise and fasting., Why is this important?, It boosts glutathione, the bodys primary antioxidant, in Glutathione: Benefits & How to Boost Levels CLNQ